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Background Joint punctures in children require adequate analgesia, sedation or both. Suitable for this are intravenous sedatives (eg propofol, midazolam) and analgetics (eg, ketamine and fentanyl). The use of these substances is safe, but requires an intravenous line, monitoring and followup. Nitrous oxide/oxygen (N2O/O2) sedation has a long-standing history of safety and success. N2O/O2 has analgic and hypnotic quality characteristics. The mask inhalation of a fixed combination of nitrous oxide with 50% oxygen causes a mean analgesia without loss of consciousness or impairment of protective reflexes for the period of inhalation.

Analgesia for joint punctures in children - experiences with a nitrous oxide / oxygen mixture (LIVOPAN®)