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Results Strong evidence for association was seen for both STAT4 (strongest effect rs7574865 OR 1.24 95%CI 1.1–1.4, ptrend = 0.0008) and TRAF1/C5 (strongest effect rs2900180 OR 1.23 95%CI 1.1–1.38, ptrend = 0.0004). The 6q23 region showed weak evidence for association with JIA (rs6920220 OR 1. 17 95% CI 1.01–1.36, ptrend = 0.03). In all cases the associated allele was the same as for RA and the effect sizes were similar.

14.5 Rheumatoid Arthritis susceptibility loci; STAT4, TRAF1/C5 and 6q23 region, are also associated with Juvenile Idiopathic Arthritis