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Results We identified 190 aPL-positive patients and randomly selected 100 patients for detailed evaluation. Sixty-two were girls and 38 boys with mean age at presentation 9.7 years. Twenty-seven (27%) patients had underlying systemic autoimmune disease (SLE 16, JIA 8). Sixty patients presented with one, 14 with two and 13 with three or more aPL-related clinical manifestations. Thromboses occurred in 10 (10%) patients and one patient had recurrent thrombosis. One or more non-thrombotic clinical manifestations were found in 77 (77%) patients including hematological disorders in 27 (thrombocytopenia 20, autoimmune hemolytic anemia 2), neurological disorders in 26 (migraine 15, seizures 3, chorea 2) and skin disorders in 22 patients (livedo reticularis 9, Raynaud's phenomenon 4). Seventeen infants born to mothers with aPL-positive autoimmune disease had positive aPL and 4 of them exhibited aPL-related clinical manifestations.

14.1 Clinical spectrum and outcome in 100 children with positive antiphospholipid antibodies