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Background Fever of unknown origin (FUO) is a diagnostic challenge in children, especially differentiation of systemic onset juvenile idiopathic arthritis (SOJIA), an autoinflammatory syndrome associated with uncontrolled activation of phagocytes. In this study, we analysed the relevance of myeloid related proteins 8 and 14 (MRP8, MRP14), two endogenous activators of toll-like receptor 4, for early diagnosis and pathogenesis of SOJIA.

The TLR4 ligands MRP8 and MRP14 in the diagnosis and pathogenesis of systemic onset juvenile idiopathic arthritis