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Methods 10 patients (3–17 yrs) with sJIA were enrolled onto a 12 week study at our institution. All patients fulfilled the ILAR classification for sJIA. Out of the 10 patients, 9 had failed anti-TNF. All patients received Anakinra at 2 mg/kg/ day subcutaneously with their current therapy, except anti-TNF. Responders met Definition of Improvement (DOI) criteria by >30% improvement in at least 3 of the six JIA core set criteria with no more than 1 criteria worsening by >30% as well as their serum SAA/CRP returning to normal. Systemic features were documented.

Experience of one UK site presenting a closer examination of safety and efficacy of Anakinra (Kineret®) in systemic juvenile idiopathic arthritis