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TNF-inhibitors have demonstrated a favourable benefit-to-risk profile. Intolerance, lost of efficacy or adverse events led to other options as the antagonist of the IL-1 receptor (Anakinra), in SoJIA.  206 pts were treated with TNF inhibitors; 45 patients (22%) were affected by SoJIA.

Anakinra in systemic juvenile idiopathic arthritis (soJIA) non responsive to antiTNF