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We have previously found specific genes upregulated in PBMCs of active sJIA [1]. Biologics to block IL-1 and IL-6 signalling have both been shown to be effective in early clinical trials. In this study we examine the expression before and after anti-IL1 and anti IL-6R treatment in PBMCs and their constitutive cell types; using gene expression analysis to further understand the disease pathways.

Gene expression in active systemic JIA after anti-IL1 and anti-IL6R treatment