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Patients The boy developed at 8 yrs musculoskeletal pain and painful nodules on the legs, than vertigo, tinnitus, and diplopia, neurosensorial ipoacusia, left central facial palsy and hypertension. Angio MRI revealed ischemic alterations on Willis's circle and prompted to diagnose PAN. Despite aggressive therapy the boy developed ischemic lesions of 3 digits of hands and Iloprost was introduced; over a short time multiple ulcerative deep cutaneous lesions appeared on the legs. Due to persistent active disease, MMF (2 g/day) was started and up to now the clinical symptoms are stable and laboratory work up normalised.

Polyarteritis Nodosa (PAN) in childhood: a report of two siblings with intractable disease controlled by mycophenolate mofetil (MMF)