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Background Juvenile-onset Systemic Lupus Erythematosus (JSLE) differs from adult-onset SLE yet few studies explore its immunopathology. We have previously demonstrated that serum from JSLE patients induces increased apoptosis in neutrophils from both healthy controls and JSLE patients, when compared to control serum. Quantification of cytokines that inhibit apoptosis were found to be decreased in JSLE serum compared to control serum. Here we aim to investigate whether the addition of these cytokines could abrogate the increased neutrophil apoptosis associated with incubation in JSLE serum.

pediatric rheumatology online journal

The addition of granulocyte macrophage colony stimulating factor (GM-CSF) to juvenile systemic lupus erythematosus serum can reduce abnormal neutrophil apoptosis