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In adults with rheumatoid arthritis several polymorphisms of C677T genotype (CT and TT) were associated with increased toxicity and higher methotrexate (MTX) efficacy. Homozygote CC polymorphism of A1298C genotype was associated with toxicity.

pediatric rheumatology online journal

MTHFR polymorphism and red cell folate levels are not useful as biomarkers of methotrexate efficacy and toxicity in children with juvenile idiopathic arthritis