English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Results Histopathology showed a mostly lobular panniculitis, without vasculitis, with a mixed inflammatory infiltrate with evolving prominent cellularity with neutrophils, then lymphocytes and finally histiocytes. Lipophagia was considered the cause of lipoatrophy. On immunohistochemistry, T-lymphocytes, both CD4 and CD8, were strongly represented, with a higher proportion of CD8. Myeloperoxidase (MPO) staining was positive in the infiltrate in all cases. MPO-positive cells were mainly located surrounding individual adipocytes. CD68/PGM1 stain was positive in all cases, and the infiltrate was more prominent in late lesions, showing prominent lipophagia. CD68/PGM1 cells were located within the infiltrate, but were also strikingly distributed around individual adipocytes. Double staining with MPO and CD68/PGM1 showed that MPO-positive and CD68/ PGM1 cells were different, thus indicating that in early stages MPO-positive cells induce damage to adipocytes and later, CD68/PGM1 macrophages will phagocyte adipocytes, leading to lipophagia and lipoatrophy. We found intensely positive stain for STAT1 in all cases, whereas STAT2 was negative in all samples. Only the cells in the inflammatory infiltrate in the fatty lobules were stained for STAT1.

Recurrent Inflammatory Panniculitis with Partial Lipoatrophy and Elevated temperature: a possible new autoinflammatory disorder