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Cryopyrin-associated periodic syndrome (CAPS), familial mediterranean fever (FMF) and tumor necrosis factor receptor-associated periodic syndromes (TRAPS) are rare systemic, monogenetic inherited autoinflammatory diseases. The clinical significance of low penetrance mutations in TRAPS and CAPS as well as heterozygosity in FMF is still under debate. The frequency and clinical pattern of peripheral and central nervous system (CNS) manifestation in those patients remain unclear.

Neurological manifestations in autoinflammatory syndromes: a series of 131 patients from our neuroimmunology departement