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FMF is the most common of the autoinflammatory diseases and is characterized by recurrent attacks of fever and painful inflammation. Treatment of colchicine reduces the frequency and severity of FMF attacks. The FMF gene, MEFV, encodes a protein called pyrin, appears to be a regulator of inflammation through its interactions with several proteins that are related to regulation of cytokine secretion, cytoskeletal signaling and cell death. ASC (Apoptosis-associated Speck-like protein containing a Caspase recruitment domain) is a pyrin-interacting protein, which is a key adaptor component of the inflammasome. In this study, we hypothesized that many anti-inflammatory drugs with different mechanisms of action may have an effect on ASC gene expression level and cellular viability.

The effect of anti-inflammatory drugs on ASC gene level and cellular viability