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Tumor necrosis factor receptor-1 associated periodic syndrome (TRAPS) is a periodic fever syndrome, characterized by recurrent fever attacks associated with rashes, musculoskeletal and abdominal pain, and periorbital edema. In few patients TNF inhibitors have been shown to be effective, however, their efficacy tends to decrease over time [1-4]. Anti-IL-1 treatments have also been used in an effort to provide long term control of the inflammatory manifestations.

pediatric rheumatology online journal

Canakinumab treatment in patients with active recurrent or chronic TNF-receptor associated syndrome (TRAPS): Efficacy and safety results from a proof of concept study