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methotrexate and 27 received both. The control group consisted of 76 healthy individuals (mean age 5.2 years). At four weeks after primary vaccination 48% of patients and 65% (P<0.01) of the controls attained seroprotection. Ninety-four percent of the patients and 99% (P=0.07) of the controls seroconverted four weeks after the second dose. Seroconversion rate was 91.5% for the patient group and 97% for the controls at 52 weeks post the second dose. Mean IgG concentration at 4 weeks was 45mIU/ml in the patient an d8 9mIU/ml in the control group (P=0.04) while it reached 118mIU/ml and 213 mIU/ml after the second dose respectively (P=0.03). Subgroup analysis showed patients on biologics had better seroconversion rates compared to children on MTX or children on biologics+MTX. Vaccines were well tolerated. Mild adverse events were noticed in 7 patients and 8 controls. None of the patients developed a flare. Conclusion Two doses of HAV vaccine are safe and effective in the majority of children with JIA, whereas a single dose seems inefficient. Systemic illness should not preclude from completion of the vaccination schedule. Seroconversion rates are lower in children whose treatment regime includes MTX. Disclosure of interest None declared.

The response to hepatitis a vaccine in children with JIA on immunosuppresive treatment