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The NLRP3 inflammasome is a key component of the innate immune system serving as an intracellular sensor of microbial components and cell injury. Gain-of-function mutations of the NLRP3 gene, such as single nucleotide polymorphism (SNP) Q705K, lead to autoproteolytic activation of caspase 1, resulting in excessive and uncontrolled production of proinflammatory cytokines. This may represent the mechanism by which an inflammatory loop is triggered leading to a long-term inflammatory phenotype.

Single nucleotide polymorphism of NLRP3 (Q705K) In juvenile spondyloarthritis and oligo/ polyarticular juvenile idiopathic arthritis