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There is a dire need of non-invasive biomarkers of lupus nephritis (LN) activity. MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs involved in the regulation of host genome expression at the post-transcriptional level. Previous miRNA expression profiling studies have generated some unique miRNA signatures (including miR-125a, miR-127, miR-146a,miR-150,miR-155) that are associated with systemic lupus erythematosus (SLE), but their role as biomarkers of LN has not been well examined.

MicroRNA's role as biomarkers of lupus nephritis in children