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compare with HLA B27+ and systemic onset arthritis. Level of IL-17A IL-1b, IL-6 (in contrast with tnfa level), was increased in patients with active HLA B27+ arthritis, if compare with other subtypes of JIA (p < 0,05). In patients with complete clinical and laboratory remission level of IL-17+T cells was reduced and almost did not differ from the control group. We also found statistically significant correlation between IL-6 level, RO+CCR6+ and the presence of osteoporosis in children with JIA. During therapy with tocilizumab expression of CCR6 and CCR4 on PBMC was decreased in patients with systemic onset JIA. Conclusion

pediatric rheumatology online journal

PReS-FINAL-2059: Th17 cells highly enriched in peripheral blood in children with HLA B27-associated arthritis and systemic onset juvenile idiopathic arthritis