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Monocytes represent essential components of innate immunity with high plasticity.These cells are characterized by their ability to release large amounts of proinflammatory cytokines, efficient antigen presentation, and microbicidal or tumoricidal activity.They contribute to inflammation in the immune system, either by governing host defense response to invading pathogens or driving reactions to self-molecules in conditions of tissue-damage. Control of these mechanisms is necessary to ensure the self-limitation of inflammatory reactions and avoid perpetuated autoinflammation or autoimmunity. In T-cells activation-induced cell death is an important mechanism for maintaining tolerance to self-antigen. However, to date it is unclear how activated monocytes can regulate early cytokine signals promoting their survival or cell death.

PReS-FINAL-2332: Activation-induced cell death of human monocytes as a novel mechanism fine-tuning inflammation and autoimmunity