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Systemic lupus erythematous (SLE) is a complex disease which is rare in childhood and can present insidiously. Libman-Sacks endocarditis (LSE) is a recognised cardiac manifestation of SLE with valvular abnormalities that are clinically silent prior to significant valve dysfunction. Multiple reports have associated isolated mitral regurgitation with SLE and the presence of antiphospholipid antibodies in SLE patients increases the prevalence of mitral valve regurgitation by three fold.

pediatric rheumatology online journal

PReS-FINAL-2307: Libman-Sacks endocarditis as a presentation for systemic lupus erythematous in an adolescent with isolated mitrial regurgitation and Noonan syndrome