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Juvenile-onset SLE (JSLE) is a severe auto-immune disease that can occur in children at any age. Variations regarding the extent of organ involvement, disease activity and damage are found in different age categories. Factors that may contribute to an earlier age of onset are gender, ethnicity and positive family history of SLE. It has been shown that JSLE has a more aggressive disease course compared to adult onset SLE. Correspondingly, it seems that disease severity in younger JSLE patients increases with decreasing age 1,2,4. However, there is some conflicting evidence.

pediatric rheumatology online journal

PReS-FINAL-2303: Exploring potential differences in demographics, family history and disease characteristics in JSLE patients with different age of onset