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Systemic onset juvenile idiopathic arthritis (SoJIA) shows properties of autoinflammatory disease, and requires the presence of arthritis and fever for diagnosis. The pro-inflammatory proteins MRP8/14 (S100A8/9) and S100A12 are biomarkers which have been shown to detect ongoing subclinical disease activity in patients with clinical remission. We compared the MRP8/14 (S100A8/9) and S100A12 biomarker profile of patients in the AID-NET (German Auto-inflammatory Disease Network) register to further provide evidence for the usefulness of measurement of these biomarkers.

PReS-FINAL-2216: Biomarkers MRP8/14 and S100A12 correspond with flare and remission clinical status in Sojia patients in the AID-NET register