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Methotrexate (MTX) is a cornerstone and safe disease-modifying anti-rheumatic drug (DMARD) in the treatment of juvenile idiopathic arthritis (JIA). Despite its safety, MTX intolerance occurs frequently, leading to non-compliance, thus hampering efficacy and potentially leading to early discontinuation.

PReS-FINAL-2162: Development of a risk model to predict methotrexate intolerance in juvenile idiopathic arthritis