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Conclusion Our finding suggests, that intestinal immune activation involving the increase of g/δ lymphocytes contributes to the pathogenesis of uveitis in children with JIA. Although both the factors inducing the intestinal mucosal immune activation in JIA and the mechanism linking intestinal activation and uveitis remain speculative, we suspect that pathological entry of the gut originating lymphocytes into the iris is possible because intensive distribution of the adhesion molecules on the endothelium of the vessels in the iris in patients with uveitis. Our finding encourages to study the potential role of gastrointestinal factors in the pathogenesis of uveitis associated with JIA. Our finding together with reports of experimental autoimmune uveitis models support the hypothesis of gut mucosa, gut lymphocyte homing receptors in the uvea, and the role of gut originating lymphocytes in the development of uveitis.

PReS-FINAL-2153: Intestinal gamma/delta- T cells are upregulated in children with active uveitis