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Monosodium urate (MSU) crystal induced interleukin-1 (IL-1β) secretion is a critical pathogenic factor in the development of gout and serves as therapeutic target in these patients. Nevertheless, without co-stimulation by a pro-IL-1s inducing factor, e.g. lipopolysaccharides (LPS), MSU alone cannot induce IL-1β secretion in vitro. The endogenous Toll-like receptor 4 (TLR-4) agonists myeloid related protein (MRP) 8 and MRP14 play a significant role in human inflammatory diseases, reflect disease activity and have been shown to be an important pathogenic factor in murine arthritis models.

OR6-004 – MRP8/14 promote MSU-crystal induced inflammation