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Background Fractional flow reserve (FFR) is an invasive diagnostic tool to evaluate the functional significance of an intermediate coronary stenosis by quantifying the pressure gradient (ΔP) across that stenosis [1]. Noninvasive ΔP measurement (ΔPMR) using phase-contrast (PC)-MRI in conjunction with Navier-Stokes (NS) equations has been attempted in large to medium size vessels [2-4], and recently been applied to smaller coronary arteries [5]. However, the measurement accuracy awaits systematic validation given that the small, tortuous, and moving caliber in the coronary artery, particularly when a stenosis exists, may elicit errors in flow velocity quantification by PC-MRI. This study aimed to investigate the feasibility of deriving ΔPMR in small caliber stenotic phantom models at various diameters and its correlation with measured ΔP values via a pressure transducer (ΔPPT).

journal of cardiovascular magnetic resonance

Pressure gradient measurement using phase contrast (PC)-MRI in stenotic phantom models: Towards noninvasive quantification of fractional flow reserve in the coronary arteries