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Background In-vivo carotid CMR is able to identify features of plaque vulnerability such as lipid core size. However, the current standard (multicontrast CMR) requires contrast media, extensive post-processing and subjective interpretation. Recently we proposed to use quantitative T2 mapping to distinguish plaque lipid from surrounding fibrous tissue and measure lipid core size. This study aimed to (1) validate plaque lipid quantification by T2 mapping against histology and (2) investigate if it could discriminate between symptomatic and asymptomatic patients.

journal of cardiovascular magnetic resonance

In-vivo carotid T2 mapping can accurately quantify plaque lipid content to discriminate between symptomatic and asymptomatic patients: histological validation, scan-rescan reproducibility and clinical study