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Methods Patients with myocardial infarction (n = 45), myocarditis (n = 25) or hypertrophic cardiomyopathy (HCM) (n = 15) were prospectively enrolled. After administration of gadolinium contrast agent, LGE images were acquired ECG-gated in short axis slices (slice thickness 7 mm, no gap) using 4 different LGE sequences: (1) conventional segmented 2D phase-sensitive inversion recovery in single-slice/single-breath-hold technique (2D-PSIR; gold standard; TR 744 ms, TE 5,17 ms, voxel size 1.4 × 1.4 × 7.0 mm), (2) single-breath-hold 3D-IR sequence (3D-IR bh; TR 924 ms, TE 1.06 ms, voxel size 1.9 × 1.9 × 7.0 mm), (3) single breath-hold 3D-SSFP sequence (3DSSFP; TE 700 ms, TE 1.05 ms, voxel size 1.9 × 1.9 × 7.0 mm) and (4) non-breath-hold technique (3D-IR nbh). (Figure 1) For all techniques, inversion time was individually adjusted to null the remote myocardium. Myocardial fibrosis was quantitatively assessed using a semiautomated threshold method; positive LGE was defined as signal intensity 6 standard deviations (SD) above signal intensity of remote myocardium for myocardial infarction and 3 SD for myocarditis / HCM. Detection rates were determined as number of matching myocardial AHA segments with detected LGE in gold standard and each fast technique.

journal of cardiovascular magnetic resonance

Equivalence of conventional and fast late gadolinium enhancement (LGE) techniques for quantitative evaluation of fibrosis in ischemic and non-ischemic cardiac disease - Save the Time!