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Background Human physiology and disease are defined by complex interactions between genetic and environmental factors. While genome-wide association studies (GWASs) have been successfully used to dissect many human traits, they have not worked for studies of the heart. This likely reflects the limitations in echocardiographic and traditional magnetic resonance phenotyping, as many cardiac traits are known to be highly heritable. In an attempt to overcome the limitations of human heart GWASs to date, we developed high-resolution 3D-cardiac MRI (3D-CMR) techniques combined with computational image analysis and dense genotyping to examine the common genetic determinants of cardiac structure and function.

journal of cardiovascular magnetic resonance

Genome wide association analysis of the heart using high-resolution 3D cardiac MRI identifies new genetic loci underlying cardiac structure and function