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Background Hypoxia induces pulmonary vasoconstriction leading to an increase in pulmonary vascular resistance and acute pulmonary hypertension (PH). It is known that with acute hypoxia, cardiac output (CO) is maintained with an increase in heart rate (HR) but a blunted stroke volume (SV) response. To our knowledge, the response of the healthy heart to acute pulmonary hypertension has not been studied using exercise cardiac magnetic resonance imaging (CMR). CMR is a highly reproducible and accurate method of evaluating biventricular function during exercise and can be used to measure real time physiological response to an increased cardiovascular workload. We aimed to study the ability of exercise magnetic resonance imaging to detect changes in right ventricular (RV) and left ventricular (LV) function during normoxic and hypoxic exercise.

Cardiac magnetic resonance imaging in healthy volunteers in normoxic and hypoxic exercise