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Background Arterial stiffness is an important predictor of risk for incident cardiovascular events. Impaired endothelial function has been related to arterial cyclic stress, large artery stiffness and remodeling. MRI has been used to noninvasively measure local aortic strain and distensibility, and regional pulse wave velocity (PWV) of the proximal aorta. We investigated the relationship between aortic size and stiffness and tissue factor pathway inhibitor (TFPI) that is an endogenous inhibitor of the procoagulant tissue factor/factor VIIa complex, known as a marker of endothelial cell dysfunction in a large population free from overt cardiovascular disease.

Relationship between tissue factor pathway inhibitor and aortic stiffness assessed by MRI: the Multi-Ethnic Study of Atherosclerosis (MESA)