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Background Patients with PAD who have intermittent claudication have reduced exercise tolerance, however, the mechanisms are not well understood. Ankle-brachial index (ABI) correlates neither with walking distance nor the degree of claudication or functional limitation as it is only able to measure flow at the macrovascular level. phosphocreatine () is a non-invasive marker of mitochondrial capacity in the skeletal muscle providing an insight into muscle metabolism and tissue perfusion. We sought to analyze the relationship of 31p recovery time constant (PCr) and exercise capacity in a population with PAD.

Phosphocreatine recovery time constant (PCr) at peak exercise as a potential endpoint for clinical trials in PAD