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Background Delayed washout of Gadolinium (Gd) contrast in the presence of myocardial scar, fibrosis, or infiltration is the basis for late Gd enhancement (LGE) imaging using cardiovascular magnetic resonance (CMR). It is also known that shortening of native, non-contrast myocardial T1 time is proportional to the degree of myocardial damage. We thus hypothesized that, compared to normal myocardium, native, non-contrast myocardial T1 time would be significantly longer in areas that would have greater Gd deposits on LGE sequences. If confirmed, this approach could potentially be used to detect damaged myocardium without contrast enhancement in patients who cannot receive Gd-based contrast agents.

journal of cardiovascular magnetic resonance

Use of non-contrast Myocardial T1 times to distinguish between fibrosis and normal myocardial tissue, a possible alternative for patients who cannot receive gadolinium-based contrast agents