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Background Characterization of infarct heterogeneity can inform therapeutic strategies for ventricular tachycardia and the management of patients with prior myocardial infarction (MI). Multi-contrast late-enhancement (MCLE) images along the signal-relaxation curve, acquired in a breath-hold ECG-gated scan, offer better visualization of MI than conventional IR-FGRE. However, current MR images either with IR-FGRE or MCLE provide an inferior spatial resolution of 1.6-2.0 mm in-plane with a slice thickness of 5-8 mm in the clinical setting, which is not sufficient to properly delineate infarct heterogeneity. This work presents a three-dimensional MCLE sequence accelerated using variable density Poisson-disk sampling and also proposes a novel reconstruction method using Compressed Sensing with Edge Preservation (COSEP), achieving an in-vivo isotropic resolution of 1.5 mm within a single breath-hold.

High-Resolution MR Characterization of Myocardial Infarction using Compressed Sensing with Edge Preservation