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Background Heart failure with preserved ejection fraction (HFpEF) is associated with a complex heterogeneous pathophysiology which is poorly understood thereby preventing appropriate diagnosis and prognosis. However, it is known that most of the cardiovascular and non-cardiac abnormalities that induce HFpEF are eventually manifested as an increase in left ventricular (LV) myocardial stiffness (MS). Therefore, we hypothesize that quantifying MS will assist in timely diagnosis of HFpEF and reveal pathophysiological conditions that are specific to the prognosis of HFpEF. Recently, with the advent of cardiac magnetic resonance elastography (cMRE) it has been feasible to estimate the shear stiffness of myocardium noninvasively. In this study, we use cMRE to estimate the change in LV MS across the cardiac cycle during disease progression in HFpEF induced pigs.

Quantification of myocardial stiffness in heart failure with preserved ejection fraction porcine model using magnetic resonance elastography