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Background Dilated cardiomyopathy (DCM) is associated with a 20% 5 year mortality rate. We identified that the presence of left ventricular (LV) midwall fibrosis, detected by CMR late gadolinium enhancement (LGE), was associated with a 5 fold increased risk of cardiovascular death and adverse events, independently of established predictors of outcome. The natural course of DCM is however variable; up to 15% of patients may recover function, with normalisation of left ventricular ejection fraction (LVEF). We sought to evaluate whether LGE, a robust predictor of clinical outcome, was predictive of remodelling in DCM.

journal of cardiovascular magnetic resonance

Evaluating the significance of left ventricular midwall fibrosis detected by late gadolinium enhancement imaging on left ventricular functional remodelling in dilated cardiomyopathy