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Background Pulmonary arterial hypertension (PAH) mainly affects the right (RV). Due to ventricular interdependence, PAH may also affect the left ventricle (LV) leading to opposite adaptive changes with an LV-atrophy and diffuse fibrosis. Strain analysis detects ventricular dysfunction even in patients with preserved ventricular function. Cardiac magnetic resonance (CMR) mapping techniques with determination of T1 and T2 relaxation times (T1 resp T2) may allow for discrimination between healthy myocardium and diffuse fibrosis in PAH patients. This study was performed to evaluate the association between myocardial changes assessed by strain analysis, and by native T1 and T2 map in patients with PAH.

journal of cardiovascular magnetic resonance

Pulmonary arterial hypertension is associated with increased T1 relaxation times and decreased left ventricular performance in spite of preserved left ventricular function