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Background Cardiovascular complications are one of the main causes of death in patients affected by systemic sclerosis (SSc). Heart involvement is characterized by myocardial fibrosis, arrhythmias, conduction system defects and pericardial inflammation. Also patients with subclinical cardiac involvement have a poor prognosis: thus early markers of heart damage are necessary to identify patients at risk. Left ventricle (LV) diastolic dysfunction evaluated with echocardiography has recently been considered as an early marker of cardiac involvement and myocardial fibrosis in SSc patients. As cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) allows an in vivo, non invasive, tissue characterization and detection of myocardial fibrosis, we evaluate the presence and extension of LGE in a population of SSc, the relationship with echocardiography diastolic dysfunction and clinical parameters to individuate a possible role of CMR in early detection of heart disease in SSc patients.

Early markers of heart damage in systemic sclerosis: role of cardiac magnetic resonance with late gadolinium enhancement