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Background Fractional flow reserve (FFR) is an invasive procedure evaluating the functional significance of an intermediate coronary stenosis in patients with coronary artery disease (CAD) [1]. Quantification of pressure gradient (ΔP) across a particular stenosis is the key to the determination of FFR. Noninvasive ΔP measurement (ΔPMR) using phase-contrast (PC)-MRI in conjunction with NavierStokes (NS) equations has been attempted in various vessels [2-4]. Our previous work has shown the feasibility of deriving ΔPMR at various vessel diameters in a phantom (fig.1a) and excellent correlation between ΔPMR and ΔP measured via a pressure-transducer (fig.1b). This study aimed to investigate the feasibility of deriving ΔPMR in healthy and diseased coronary arteries.

journal of cardiovascular magnetic resonance

Pressure gradient measurement in the coronary artery using phase contrast (PC)-MRI: initial patient results towards noninvasive quantification of fractional flow reserve