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Background Left Atrial scar imaging using delayed enhancement MRI (DE-MRI) has been proposed as a promising tool to guide ablation strategies in patients with atrial fibrillation (AF). Studies have shown that the scar areas detected by DE-MRI correlate with the low voltage areas on the co-registered electroanatomic voltage map based on surface matching. However, such matching methods did not consider the misalignment of the scar areas: a point-to-point comparison between DE-MRI and voltage map remains problematic. In this study, we proposed a robust 4D (3D of geometry and 1D of scar degree) registration algorithm for the point-to-point comparison of DE-MRI and voltage map. Based on the registered images, we hypothesized that by utilizing complex image information extracted from DE-MRI, we were able to predict the low voltage areas in the coregistered voltage maps.

journal of cardiovascular magnetic resonance

Comparison of noninvasive three dimensional delayed enhancement MRI of left atrial scar with invasive voltage map by using robust 4D point-to-point registration in patients with atrial fibrillation