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Background Cardiac stress testing is the standard of care for diagnosing ischemic heart disease. Traditional stress testing involves physical or pharmacological stress to induce hyperemia and/or increase myocardial oxygen demand. Physical stress is not possible in 100% of cases however, and pharmacological stress carries rare but serious risk. We asked whether acute isocapnic hypoxia could be utilized as an alternative cardiovascular stress test.

Changes in left ventricular function and coronary blood flow velocity during isocapnic hypoxia: A cardiac magnetic resonance imaging study