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Background In stable coronary artery disease (CAD), accurate ischemia detection enables targeted revascularization, which improves clinical outcomes. Myocardial blood volume (MBV) may be a better ischemia marker than myocardial blood flow. Adenosine stress and rest T1-mapping is a novel gadolinium-free CMR technique that reflects changes in MBV through its water content. We hypothesized that different myocardial tissues in CAD patients and controls have distinctive T1-responses to adenosine, enabling ischemia detection without gadolinium agents.

journal of cardiovascular magnetic resonance

Adenosine stress and rest T1-mapping differentiates ischemic, infarcted, remote and normal myocardium - a novel gadolinium-free method for ischemia detection with immediate applications in coronary artery disease