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Background About half of all women who present with symptoms of ischemic heart disease have no obstructive coronary artery disease. These women are often deemed “low-risk” patients according to conventional cardiology wisdom. The Women’s Ischemia Syndrome Evaluation (WISE) studies have demonstrated suspected coronary microvascular dysfunction (CMD) in women with persistent angina, evidence of ischemia by stress test and no obstructive coronary artery disease (CAD), defined as >50% stenosis. Women with suspected CMD also carry a higher risk of major adverse cardiac events including heart failure (HF). It is also known that diffuse myocardial fibrosis and reduced diastolic function are features in HF. The physiological mechanism behind increased HF in suspected CMD is not known. We assessed the hypothesis that function would be reduced along with previously shown elevated native myocardial T1 in suspected CMD.

journal of cardiovascular magnetic resonance

Tissue characterization with native T1 mapping in suspected coronary microvascular dysfunction and no obstructive coronary artery disease: results from the NHLBI-sponsored WISE study