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Background Patients with single ventricle (SV) circulations are at risk for heart failure, frequently burdened by both systolic and diastolic cardiac dysfunction. The mechanisms of adverse remodeling of functionally univentricular hearts are incompletely understood. Diffuse myocardial fibrosis is one of the candidate morphological substrates, for which cardiac magnetic resonance (CMR) derived native T1 times and extracellular volume fraction (ECV) have been used as markers. The purpose of this pilot study was to explore whether there is evidence of accelerated myocardial fibrosis in young children after the Fontan operation using CMR.

Diffuse myocardial fibrosis in patients after Fontan operation: a T1 relaxometry magnetic resonance pilot study