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Background BOLD CMR is a non-contrast approach for examining myocardial perfusion but despite major technical advancements to date, its reliability remains weak. A key reason for this is the unpredictable cardiac motion during stress, which can lead to pronounced artifacts that confound/ mask the true BOLD signal changes during hyperemia. Recently, regadenoson has become the vasodilator of choice owing to greater patient tolerability and ease of use. We hypothesized that at 10-mins post regadenoson administration (p.r.a), (a) BOLD CMR artifacts at stress are markedly reduced compared to those conventionally acquired at 2-mins p.r.a; and (b) that myocardial perfusion reserve (MPR) remains greater than 2.0 and is highly correlated with the BOLD effects estimated from T2 maps.

journal of cardiovascular magnetic resonance

Towards reliable myocardial blood-oxygen-level-dependent (BOLD) CMR using late effects of regadenoson with simultaneous 13n-ammonia pet validation in a whole-body hybrid PET/MR system