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Background Measurement of myocardial extracellular volume fraction (ECV) with T1 mapping cardiac magnetic resonance (CMR) before and after the application of a gadolinium-based extracellular contrast agent enables the assessment of diffuse myocardial fibrosis. The equilibrium between blood and myocardium contrast concentration required for ECV measurements can be achieved with a primed contrast infusion (equilibrium contrastCMR). In healthy volunteers it could be shown that a single bolus may also be sufficient to reach equilibrium. We hypothesized that equilibrium between blood and myocardium contrast distribution can be achieved with the bolus-only technique to accurately measure diffuse myocardial fibrosis in patients with congenital heart disease (CHD).

Cardiac T1 mapping in congenital heart disease: bolus versus infusion protocol for measurement of myocardial extracellular volume