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Background Reperfusion injury in acute myocardial infarction (MI) results in edema, necrosis, microvascular obstruction (MVO), and intramyocardial hemorrhage (IMH), the latter presents an interesting clinical target. [1] Cardiovascular MRI has been shown capable of characterizing all of these tissue components. Other than MVO, which is currently detected by flow-deficient regions in contrast enhanced imaging, all other tissue components can be identified by T1 and T2 (T2*). Theoretically, the byproducts of blood breakdown observed with IMH lead to decreased T1 and T2 (T2*). [2] Conversely, free water accumulation (edema) and necrosis lead to increased T1 and T2. [2] Hence, direct and quantitative measurement of relaxation rates is promising in myocardial tissue characterization, avoiding ambiguity typical of weighted images (i.e. T2-weighted spin-echo), undesired signal loss from T2* (weighted) images or the uncertainty introduced by contrast agent kinetics. Hypothesis: Combined T1 and T2 mapping can characterize reperfused MI without contrast agents.

Non-contrast T1 and T2 relaxometry characterizes reperfusion injury of acute MI in swine