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Background The homogeneous distribution of collagen in diffuse myocardial fibrosis renders the disease unsuitable for imaging using late gadolinium enhancement (LGE) [1]. More recently, the estimation of extracellular volume from T1 maps involving gadolinium agents has shown promise; however, these methods are not specific to collagen and are governed by gadolinium kinetics [2]. The diagnosis of diffuse myocardial fibrosis would benefit from an imaging method that can directly detect collagen. Notably, ultra-short echo time magnetic resonance (UTE MR) is a technique that can be used to detect short T2* species, including collagen [3]. Our objective is to characterize the UTE signal of protons in the collagen molecule, including their T2* and chemical shift. Direct isolation of a collagen signal could aid in the diagnosis of myocardial fibrosis, especially for diffuse distributions, and the assessment of disease extent.

Characterization of the ultra-short echo time magnetic resonance (UTE MR) collagen signal associated with myocardial fibrosis