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Background Obesity has become increasing prevalent in western society and is associated with increased risk of heart failure [1]. Increased body weight is independently associated with impaired myocardial perfusion reserve (MPR), even in the absence of obstructive coronary artery disease [2]. Mouse models can elucidate molecular mechanisms that underlie cardiovascular disease. In this study, we used in vivo cardiac MRI in a mouse model of diet-induced obesity to establish the time course of MPR and we further used ex vivo histological and vascular reactivity studies to elucidate factors underlying the MRI results.

Cardiac MR detects the progression of impaired myocardial perfusion reserve in a mouse model of obesity-related cardiomyopathy