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Background Recently, we could demonstrate in humans that (ultrasmall) superparamagnetic iron-oxide (U/SPIO)-based contrast agents enable a detailed characterization of myocardial infarct pathology. Considering the multifunctionality of U/SPIO-based nanoparticles (magnetic targeting as well as diagnostic imaging properties) and their superior safety profile compared to gadoliniumbased compounds, we performed ex vivo analyses and evaluated the magnetic navigating/targeting properties of U/SPIO.

journal of cardiovascular magnetic resonance

External targeted navigation of ultra-small iron-oxide (U/SPIO) nanoparticles by an external permanent magnet - proof-of-principle as a prerequisite for magnetic drug delivery using U/SPIO